Negative alactic base excess is reversed by hemoperfusion in septic patients

Introduction: Gattinoni et al. have recently introduced a new parameter: the "alactic base excess"(ABE). ABE is equivalent to the number of strong acids, other than lactate, which are present in the plasma in abnormal concentrations, negative ABE being associated with higher mortality in sepsis. Hemoperfusion (HPF) is an extracorporeal procedure that involves the passage of blood through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material. Then, it was decided to explore the influence of HPF on negative ABE value in sepsis. Material(s) and Method(s): Basal values of ABE, standard base excess (SBE), and lactate (mean, standard deviation [SD]) were obtained. The difference between these parameter values before and after four sessions of HPF (HA330) (delta value) was evaluated. Student's t-test and Wilcoxon test were applied. Result(s): From 32 patients (age: 57+/-13) suffering from respiratory insufficiency secondary to COVID-19 who were treated with HPF in the critical care unit of Clinica de la Mujer, Bogota (Colombia), 6 patients presented with metabolic acidosis with negative ABE value (-2.7+/-1) with negative SBE (-4.7+/-1) and high lactate serum value (2+/-0.7 mmol/L). Delta ABE, SBE, and lactate were: 7.7 (p = 0.005), 6.1 (p = 0.003), and 1.6 (p = NS), respectively. Thus, negative ABE was significantly reversed by HPF, since SBE value turned positive without significant change in lactate. Conclusion(s): Negative alactic parameter was significantly reversed by HPF in septic patients. It is necessary to carry out evaluations in larger groups to estimate their impact on clinical outcomes. Copyright © 2022 The Authors.

Atmospheric and climatic aspects in the expansion of the pandemic (covid-19) in the province of alicante

The COVID-19 pandemic has become one of the biggest recent challenges that science has encountered. A multitude of studies aim to respond to the spread of this coronavirus, hitherto unknown, under certain atmospheric and climatic conditions. The study of parameters such as temperature, humidity, and radiation in the months of February and March 2020, as well as a correlative analysis with various other variables, aims to weigh the weight that these variables could have in the expansion of this pathogen in the province of Alicante. The results indicate, in a preliminary manner, that the only variable that is related to the contagion and death rates are the maximum temperatures. This fact could be related to the climatic niche of the coronavirus and could be decisive in its expansion worldwide. The lack of information on the above rates at municipal level, as well as the absence of mobility data on such a small scale, prevents the drawing of definitive conclusions. © 2020 Interuniversity Institute of Geography and University of Alicante. All rights reserved.